MET kinase domain DMS

Source code and data for the analysis and figure generation in Estevam et al., 2023 ("Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain")

doi: https://doi.org/10.1101/2023.08.03.551866

Primary analysis of fitness scores, heatmaps, and PDB mapping can be found in:

• Met_V2.Rmd
• MET_DMS_analysis_plots.R
• dms_analysis_utilities.R

Fitness scores

Wild type MET ICD scores: ex14_scores.csv
Exon 14 skipped MET ICD scores: met_scores.csv