[Text and logical def] conjunctiva goblet cell

[Caroline-99]

CL term
conjunctiva goblet cell

Suggested revision of textual definition

A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules, primarily MUC5AC in humans and Muc5ac/Muc5b in mice. These gel-forming mucins are essential for tear film stability, ocular lubrication, and pathogen defence. This cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-2 in mice, claudin-10 in humans). The transcription factor SPDEF is essential for its differentiation.

PMID: 27091323
PMID: 31734511
https://iovs.arvojournals.org/article.aspx?articleid=2353928 ?

LLM R1 perplexity model output using a prompt:

A conjunctival goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (primarily MUC5AC in humans 157 and Muc5ac/Muc5b in mice 17) which compress the nucleus basally. These cells form tight junctions with neighboring epithelial cells through species-specific claudins (claudin-2 in mice 1, claudin-10 in humans 17) and exhibit regional distribution variations, with highest density in the nasal conjunctiva of humans 17. They secrete gel-forming mucins critical for tear film stability, ocular surface lubrication, and pathogen defense 7916. Development requires transcription factors SPDEF 8, FoxA1, and FoxA3 6, with differentiation from bipotent conjunctival keratinocytes 17. Their numbers decrease in ocular surface disorders like Sjögren syndrome, correlating with reduced mucin production 514. Immune interactions include antigen presentation to dendritic cells via crypt-like structures 1012.

Suggested revision of logical definition
goblet cell and part of some epithelium of conjunctiva