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gennadygorin authored Sep 10, 2023
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[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.8122410.svg)](https://doi.org/10.5281/zenodo.8122410)

# Overview
This repository contains all of the simulation and analysis code for the manuscript ["Transient and delay chemical master equations"](https://www.biorxiv.org/content/10.1101/2022.10.17.512599v1), a discussion of the prospects for solving and applying delay master equations in the context of RNA sequencing. In the first part of the report, we numerically solve a fairly generic set of systems with gene switching and mixed Markovian/non-Markovian downstream processing. In the second part, we analytically solve a set of bursty two-species systems with delayed steps, fit single-cell and single-nucleus RNA sequencing data, and compare the fits to draw conclusions about model suitability and identifiability.
This repository contains all of the simulation and analysis code for the manuscript "Assessing Markovian and delay models for single-nucleus RNA sequencing," a discussion of the prospects for solving and applying delay master equations in the context of RNA sequencing. In the first part of the report, we numerically solve a fairly generic set of systems with gene switching and mixed Markovian/non-Markovian downstream processing. In the second part, we analytically solve a set of bursty two-species systems with delayed steps, fit single-cell and single-nucleus RNA sequencing data, and compare the fits to draw conclusions about model suitability and identifiability.

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