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2019/06/25-07:42:50 (Linux sirius unknown)
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Philipp Benner committed Jun 25, 2019
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Expand Up @@ -180,7 +180,7 @@ This command outputs tables with identified peaks, i.e. all regions with probabi

### Estimating Single-Feature Models

For detecting peaks, i.e. for separating signal from noise, ModHMM by default uses a single-feature mixture model that was estimated on either a mouse or human data set. It uses quantile-normalization to fit the provided data to the default model before evaluating genome-wide peak probabilities. This procedure allows to easily apply ModHMM to new data sets, but is less accurate than using a model that was estimated from the actual data at hand.
For detecting peaks, i.e. for separating signal from noise, ModHMM by default uses a single-feature mixture model that was estimated on either a mouse or human data set. It uses quantile-normalization to fit the provided data to the default model before evaluating genome-wide peak probabilities. This procedure allows to easily apply ModHMM to new data sets, but might be less accurate than using a model that was estimated from the actual data at hand.

The following command estimates a new single-feature model for all features:
```sh
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